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Product Name
:
TIOSYD
Chemical Name
:
Tioconazole
Therapeutic Category
:
Antifungal drugs & Antiviral drugs
Pharmacologic Category
:
Antifungal Agent, Vaginal
Pharmaceutical Form
:
Cream
Composition
:
Tioconazole 1%
Adverse Reactions
Monitoring Parameters
Dosing
 
Dosing: Adult
Vulvovaginal candidiasis: Vaginal: Insert 1 applicatorful in vagina, just prior to bedtime, as a single dose

Dosing: Geriatric

Refer to adult dosing.
Use
 
Local treatment of vulvovaginal candidiasis
Contraindications
 
Hypersensitivity to tioconazole or any component of the formulation
Warnings / Precautions Drug
 
Concerns related to adverse effects:
• Irritation: If irritation or sensitization occurs, discontinue use.
Dosage form specific issues:
• Petrolatum-based: Petrolatum-based vaginal products may damage rubber or latex condoms or diaphragms; separate use by 3 days.
Metabolism/Transport Effects
Inhibits CYP1A2 (weak), 2A6 (weak), 2C9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak)
Interactions
 
There are no known significant interactions.
Pregnancy
 
C
Lactation
 
Excretion in breast milk unknown/not recommended
Mechanism of Action
 
A 1-substituted imidazole derivative with a broad antifungal spectrum against a wide variety of dermatophytes and yeasts, including Trichophyton mentagrophytes, T. rubrum, T. erinacei, T. tonsurans, Microsporum canis, Microsporum gypseum, and Candida albicans. Both agents appear to be similarly effective against Epidermophyton floccosum.
Pharmacodynamics / Kinetics
 
Onset of action: Some improvement: Within 24 hours; Complete relief: Within 7 days
Absorption: Intravaginal: Systemic (small amounts)
Distribution: Vaginal fluid: 24-72 hours
Excretion: Urine and feces
 
   
 
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