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Product Name
Chemical Name
Benzydamine HCl
Therapeutic Category
Respiratory tract drugs
Pharmacologic Category
Local Anesthetic, Oral
Pharmaceutical Form
Benzydamine HCl 0.15%
Monitoring Parameters
Dosing: Adult
Acute pharyngitis: Oral rinse: Gargle with 15 mL of undiluted solution every 11/2-3 hours until symptoms resolve. Patient should expel solution from mouth following use; solution should not be swallowed.
Mucositis: Oral rinse: 15 mL of undiluted solution as a gargle or rinse 3-4 times/day; contact should be maintained for at least 30 seconds, followed by expulsion from the mouth.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment

No adjustment required.
Symptomatic treatment of pain associated with acute pharyngitis; treatment of pain associated with radiation-induced oropharyngeal mucositis
Adverse Reactions
Central nervous system: Drowsiness, headache
Gastrointestinal: Nausea and/or vomiting (2%), xerostomia
Local: Numbness (10%), burning/stinging sensation (8%)
Respiratory: Cough, pharyngeal irritation
Hypersensitivity to benzydamine or any component of the formulation
Warnings / Precautions Drug
Concerns related to adverse effects:
• Irritation/burning: May cause local irritation and/or burning sensation in patients with altered mucosal integrity; dilution (1:1 in warm water) may attenuate this effect.
Disease-related concerns:
• Renal impairment: Use with caution in patients with renal impairment.
Metabolism/Transport Effects
Substrate (minor) of CYP1A2, 2C19, 2D6, 3A4
There are no known significant interactions.
Pregnancy Implications
Safety has not been established in pregnant women. Use only when potential benefit outweighs possible risk to the fetus.
Excretion in breast milk unknown/use caution
Mechanism of Action
Local anesthetic and anti-inflammatory, reduces local pain and inflammation. Does not interfere with arachidonic acid metabolism.
Pharmacodynamics / Kinetics
Absorption: Oral rinse may be absorbed, at least in part, through the oral mucosa
Excretion: Urine (primarily as unchanged drug)
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