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Product Name
:
MERGOTRINE (amp)
Chemical Name
:
Methylergometrine maleate
Therapeutic Category
:
Miscellaneous drugs
Pharmacologic Category
:
AUterine stimulant
Pharmaceutical Form
:
Ampoule
Composition
:
Methylergomtrine maleate 0.2mg/1ml
Lactation
Monitoring Parameters
Pharmacodynamics / Kinetics
Dosing
 
Tablets: -Subinvolution, lochiometra, puerperal bleeding: 0,125 to 0,250 mg p.o. (1-2 tablet daily) in lactating women preferably for no longer than 3 days.

Ampoules: -Active management of the third stage of labour. 0.1 to 0.2 mg slowly I.M following the delivery of the anterior shoulder or, at the latest, immediately after delivery of the child. Expulsion of the placenta-usually separated by the first strong contraction following Mergotrine – should be manually assisted. -For delivery under general anaesthesia the recommended dose is (0.2 mg)
Use
 
Active management of the third stage of labour -Treatment of uterine atony/haemorrhage occurring. -during and after the third stage of labour -in association with caesarean section -following abortion. -Treatment of subinvolution of the uterus, loc
Adverse Reactions
 
In few cases: Abdominal pain (caused by uterine contractions); nausea, vomiting, sweating, dizziness, headache; skin eruptions. -Very rarely hypertension, bradycardia or tachycardia. -In very few cases anaphylactic reactions (dyspnoea, hypotension, shock) occurred. Note : It is recommended with the prescription of the physician.
Contraindications
 
Pregnancy, first stage of labour, second stage of labour before crowning of the head (Mergotrine must not be used for induction or enhancement of labour) Severe hypertension, hypertensive toxaemia (pre-eclampsia, eclampsia); occlusive vascular disease (incl. ischemic heart disease) sepsis; hypersensitivity to ergot alkaloids.
Warnings / Precautions Drug
 
Mergotrine passes into the milk but, the doses which reach the newborn is very small.By any case the patient must consult his physcian. Care should be taken if it is prescribed in patients with renal or hepatic failure. Intravenous injection should be given slowly over a period of no less than 60 seconds.
Interactions
 
Mergotrine may enhance the vasconstrictor/vasopressor effects of other drugs such as sympathomimetics (e.g. used with local anaesthetics) or ergotamine. No adverse interactions are known to occur with the concurrent administration of Mergotrine and oxytocin. For prevention and treatment of uterine heamorrhage by intramuscular injection it may be advantageous to combine the two uterotonic princip .
Pregnancy
 
D
Mechanism of Action
 
Methylergometrine, a semisynthetic derivative of the naturally occurring alkaloid ergometrine, is a potent and specific uterotonic agent. Compared with the alkaloids of the ergotamine group its effect on peripheral vessels. PHARMACOKINETICS: The absorption of Mergotrine following both oral and intramuscular administration is rapid, the maximum plasma concentration being reached after 30 minutes. In the puerperium gastrointestinal absorption is slower, and the maximum plasma concentration is reached after 3 hours. Only about 3% of an oral dose is eliminated as parent drug in the urine, indicating extensive metabolism. The drug is mainly eliminated with the bile into the faeces. The onset of action of Mergotrine occurs in 30-60 seconds after i.v(2-5) minutes after i.m. and 5-10 minutes after oral administration and lasts for 4-6 hours.
 
   
 
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