CLINDO (gel)
-
Chemical Name:
Clindamycin (Phosphate) -
Therapeutic Category:
Antimicrobial -
Pharmacologic Category:
Antibiotic, Lincosamide -
Pharmaceutical Form:
Gel -
Composition:
Clindamycin (Phosphate) 1%
CLINDO
Topical Gel
Clindamycin (Phosphate)
1. PHARMACOLOGY:
Clindamycin inhibits bacterial protein synthesis at the level of the bacterial ribosome. The antibiotic binds preferentially to the 50S ribosomal subunit and affects the process of peptide chain initiation.
Clindamycin in vitro inhibits all Propionibacterium acnes cultures tested (MICs 0.4 mcg/ml).
2. PHARMACOKINETICS:
Although clindamycin phosphate is inactive in vitro, rapid in vivo (on the skin) hydrolysis converts this compound to the antibacterially active clindamycin.
Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per gr, very low levels of clindamycin are present in the serum (0.3ng/ml) and less than 0.2% of the dose is recovered in urine as clindamycin.
3. INDICATIONS:
CLINDO topical gel is indicated in the treatment of acne vulgaris.
4. CONTRAINDICATIONS:
CLINDO topical gel is contraindicated in individuals with a history of hypersensitivity to clindamycin or lincomycin. CLINDO topical gel is contraindicated in individuals with a history of regional enteritis, ulcerative colitis, or a history of “antibiotic-associated” colitis.
5. PRECAUTIONS:
This drug should be used during pregnancy only if clearly needed.
6. SIDE EFFECTS:
Sometimes, itching, local irritation, skin dryness and sometimes diarrhea due to systemic absorption.
7. DRUG INTERACTIONS:
CLINDO topical gel may be used with anti-acne drugs.
It must not be co-administered with erythromycin.
8. DOSAGE & ADMINISTRATION:
CLINDO is applied as thin film of clindamycin phosphate topical gel twice daily on the affected areas.
9. PACKAGING & COMPOSITION:
CLINDO – Topical Gel: A aluminium tube of 20 g topical gel. Each gram contains Clindamycin Phosphate equivalent to 10 mg Clindamycin.
10. STORAGE CONDITIONS:
Store CLINDO – Topical Gel at temperature between (15-30)°C.
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